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文献和实验Purification and Crystallization of NS5A Domain I of Hepatitis C Virus
The NS5A protein of HCV is an essential component of the viral RNA replication machinery and may also function in modulation of the host cell environment. The exact function of NS5A in these processes remains unknown. NS5A is a large
Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)
enzymes that replicate the genomic RNA of plus strand RNA viruses (9 –11 ). A model enzyme of this group, the poliovirus RDRP encoded by the 3Dpol gene, has been extensively studied (12 –17 ). However, studies of recombinant hepatitis C virus RDRP
Hepatitis C Virus: Types, Subtypes, and Beyond
Non-A, non-B hepatitis was recognized as a frequent consequence of blood transfusion for many years before the agent responsible, hepatitis C virus (HCV), was first cloned and sequenced in 1989 Very quickly it became apparent
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