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文献和实验Typing of Tumor Necrosis Factor Alleles
The tumor necrosis factor (TNF) locus contains the three closely related cytokine genes: TNF , and lymphotoxin α and �. The gene cluster lies at the telomeric end of the class III region of the major histocompatibility complex (MHC
Tumor Necrosis Factor as a Pharmacological Target
Tumor necrosis factor (TNF) was originally described as a molecule with antitumor properties released by macrophages stimulated with bacterial products. Almost at the same time that TNF was cloned, it was found to be identical to cachectin
Assay of Soluble Tumor Necrosis Factor Receptors
Over the last decade, numerous basic biological as well as experimental and clinical studies have firmly established the significance of tumor necrosis factor (TNF) as a principal proximal mediator of sepsis (1 –
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