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文献和实验Ex Vivo Stromal Cell Electroporation of Factor IX cDNA for Treatment of Hemophilia B
Hemophilia B is an X-linked genetic disorder that typically results from chronic circulating deficiency of blood coagulation factor IX (FIX) (1). While the occurrence of hemophilia B is significantly less frequent than hemophilia A (factor
Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 Axis
The hallmark of hematopoietic stem and progenitor cells (HSPCs) is their motility, which is essential for their function, such as recruitment upon demand. Stromal Derived Factor-1 (SDF-1, CXCL12) and its major receptor CXCR4 play major roles
Assessment of Megakaryocyte Migration and Chemotaxis
cell-derived factor 1α (SDF1α) also known as CXCL12 has been described to act as a potent chemoattractant for MKs (1, 2). This biological effect is mediated by the SDF1α receptor CXCR4 (Fusin), which is expressed on haematopoietic stem cells, MKs
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