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- 详细信息
- 技术资料
- 亚型:
IgG
- 形态:
液体
- 保存条件:
-20℃
- 克隆性:
多克隆
- 标记物:
无
- 适应物种:
HMR
- 抗原来源:
兔
- 供应商:
万类生物
- 宿主:
兔
- 应用范围:
WB
- 抗体英文名:
T-bet antibody
- 规格:
50μl(>50μg)
产品概述
The T-box gene family consists of transcription factors characterized by a related DNA-binding domain (T-box) of approximately 200 amino acids. The T-box genes exhibit diverse temporal and spatial patterns in the developing embryo. TBX21 is a member of a phylogenetically conserved family of proteins that share a common DNA-binding domain, the T-box. TBX21 is the human ortholog of mouse Tbx21/Tbet protein. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
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