- 详细信息
- 申请记录(3)
- 技术资料
- 亚型:
IgG
- 形态:
液体
- 保存条件:
-20℃
- 克隆性:
多克隆
- 标记物:
无
- 适应物种:
HMR
- 保质期:
一年
- 抗原来源:
兔
- 供应商:
万类生物
- 宿主:
兔
- 应用范围:
WB,IHC,IF
- 浓度:
>1 mg/ml
- 靶点:
mature-IL1β
- 抗体英文名:
mature-IL1β antibody
- 抗体名:
mature-IL1β 抗体
- 规格:
20μl(>20μg)
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产品概述
Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. IL-1β is a pro-inflammatory cytokine produced predominantly by activated monocytes and epithelial cells. Precursor IL-1β is cleaved by caspase-1 and mature IL-1β is then secreted. Signaling by IL-1β involves IL-1β binding to IL-1 accessory protein (IL-1-AcP) and then the complex binds to IL-1RI. ignaling is through activation of MAP kinase and NF-κB pathways. IL-1β also binds to IL-1RII that lacks an intracellular signaling domain and thereby serves as a high affinity decoy receptor. IL-1β binding to IL-1RI is inhibited by the negative regulator, IL-1R antagonist (IL-1Ra).
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申请记录
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