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- 详细信息
- 询价记录
- 技术资料
- 亚型:
IgG
- 形态:
液体
- 保存条件:
-20℃
- 克隆性:
多克隆
- 标记物:
无
- 适应物种:
HMR
- 保质期:
一年
- 抗原来源:
兔
- 供应商:
万类生物
- 宿主:
兔
- 应用范围:
WB,IHC,IF
- 浓度:
>1 mg/ml
- 靶点:
HMGB1
- 抗体英文名:
HMGB1 antibody
- 抗体名:
HMGB1 抗体
- 规格:
50μl(>50μg)
产品概述
HMGB1 belongs to high mobility group and contains HMG-box domain. Like the histones, HMGB1 is among the most important chromatin proteins. The presence of HMGB1 in the nucleus depends on posttranslational modifications. When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol. HMGB1 is an intracellular protein that can translocate to the nucleus where it binds DNA and regulates gene expression. HMGB1 can interact with TLR ligands and cytokines, and activates cells through the multiple surface receptors including TLR2, TLR4, and RAGE. HMGB1 has been proposed as a target for cancer therapy.
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