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- 详细信息
- 技术资料
- 亚型:
IgG
- 形态:
液体
- 保存条件:
-20℃
- 克隆性:
多克隆
- 标记物:
无
- 适应物种:
HMR
- 保质期:
一年
- 抗原来源:
兔
- 供应商:
万类生物
- 宿主:
兔
- 应用范围:
WB
- 浓度:
>1 mg/ml
- 靶点:
HDAC1
- 抗体英文名:
HDAC1 antibody
- 抗体名:
HDAC1 抗体
- 规格:
50μl(>50μg)
产品概述
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing.
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