Nauclefine,57103-51-2

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Nauclefine

CAS No. : 57103-51-2

MCE 国际站：Nauclefine

产品活性：Nauclefine 是一种从 Nauclea officinalis 中分离出来的吲哚类生物碱。Nauclefine 可作为一种 PDE3A 调节剂，通过 PDE3A-SLFN12 依赖的死亡途径诱导癌细胞凋亡(apoptosis)。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Phosphodiesterase (PDE)  |  Apoptosis

In Vitro: Nauclefine (250?nM, 48 h) can inhibit the viability of HeLa cells and induce apoptosis, resulting in cell death dependent on PDE3A and SLFN12. Nauclefine can bind PDE3A, but does not inhibit its phosphodiesterase activity, can promote the interaction between PDE3A and SLFN12, and promote cell death by increasing the stability of SLFN12.

In Vivo: Nauclefine (5 mg/kg, intratumorally, once per day for 22 days) significantly reduces the overall growth of HeLa-luc cell tumors in female nude mice (Balb/c-nu) infected with HeLa cells, especially after treatment 6 Days later, the tumor volume is significantly reduced without causing any decrease in the body weight of the mice. Its inhibition of tumor growth depends on the expression of PDE3A and SLFN12.

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