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92214-56-7
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Phorbol 12-tiglate
CAS No. : 92214-56-7
MCE 国际站:Phorbol 12-tiglate
产品活性:Phorbol 12-tiglate 是 Phorbol (HY-N2147) 的衍生物。Phorbol 是巴豆油的水解产物,能够通过激活蛋白激酶 C 而促进肿瘤发展。Phorbol 及其衍生物可用于生物医学研究中致癌模型的构建。
研究领域:Others
作用靶点:Others
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文献和实验The term phorbol is loosely used to describe a family of naturally occurring compounds referred to as tiglian diterpenes. These are widely distributed in the plant species of the families Euphorbiaceae and Thymelaeaceae. This chapter
致癌助催剂(promoter)。系从大戟科(Euphorbiaceae)植物巴豆(Croton tiglium)种子搾取获得的巴豆油中所含的促致癌活性成分。也称为TPA(12-0-四癸酰基佛博尔13-乙酸)或PMA(佛博尔豆蔻乙酸)。
Cultivation of Normal Human Epidermal Melanocytes in the Absence of Phorbol Esters
skin, was initially achieved by suppressing the growth of keratinocytes and fibroblasts in epidermal cell suspensions with the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) and the intracellular cyclic adenosine 3’ , 5’ monophosphate (cAMP
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