In Vivo: Insulin peglispro (BIL) (s.c., 17, 0.45 or 1.15 mg/kg/d, 52 week) has no effect on Crl:CD(SD) rat survival at any dose, resulting in some increase in body weight. Serum glucose concentrations are unaffected at an administered dose of 0.17 mg/kg, while 0.45 mg/kg shows lower serum glucose concentrations at 3 and 6 hours post-dose on day 1.