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Thrombin inhibitor 7
CAS No. : 2866508-00-9
MCE 国际站:Thrombin inhibitor 7
产品活性:Thrombin inhibitor 7 是一种有效的 FXIIa 抑制剂,对 FXIIa 和 FXIa 的 IC50 值分别为 28 nM 和 >132 µM。Thrombin inhibitor 7 具有低细胞毒性。
研究领域:Others
作用靶点:Others
In Vitro: Thrombin inhibitor 7 (compound 33b) (0-300 µM; 24 h) shows low cytotoxicity in HepG2, A549 cells.
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文献和实验Oral Thrombin Inhibitor Ximelagatran
Preclinical and initial clinical experiences with the direct oral thrombin inhibitor ximelagatran demonstrated both a short and long-term potential utility for this agent in the prevention and treatment of various thromboembolic disorders
at the meeting of the International Society in Thrombosis and Haemostasis in 1993. AT is an important protease inhibitor of thrombin and factor Xa. However, AT is also able to inhibit factors IXa, XIa, XIIab, kallikrein, and plasmin. Given
Antiplatelet, Anticoagulant, and Thrombolytic Drug Interactions
, but heparin anticoagulation is unpredictable because it is an indirect thrombin inhibitor, which requires heparin cofactor II-antithrombin for its actions. Antithrombin levels vary widely in patients. In addition, the heparin-antithrombin complex is too large
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