- 询价
- MedChemExpress(MCE)
- 美国
- HY-125065
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Please store the product under the recommended conditions in the Certificate of Analysis.
- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- CAS号：
796885-38-6
- 规格：
询盘
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
MK-4541
CAS No. : 796885-38-6
MCE 国际站：MK-4541
产品活性：MK-4541 是一种选择性、口服有效的雄激素受体 (AR) 调节剂。MK-4541 可作为拮抗剂抑制 5α-还原酶。MK-4541 抑制 AR 阳性前列腺癌细胞的增殖并诱导凋亡 (apoptosis)。MK-4541可显著抑制 R3327-G 前列腺肿瘤在异种移植小鼠模型中的生长。
研究领域：Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease
作用靶点：Androgen Receptor | 5 alpha Reductase
In Vivo: MK-4541 (100 mg/kg; p.o.; 5 times per week for 5 weeks) inhibits prostate tumor growth in athymic nude mice bearing R-3327-G cells.
MK-4541 (100 mg/kg, 200 mg/kg; p.o.; 5 times per week for 5 weeks) exhibits anti-androgen effects on the seminal vesicles, reduces plasma testosterone concentrations in intact males, and inhibits Ki67 expression.
MK-4541 (15 mg/kg, 50 mg/kg; p.o.; 5 times per week for 8 weeks) causes the loss of musculoskeletal mass and function in adult castrated mice.
相关产品：Enzalutamide | DHEA | Bavdegalutamide | Medroxyprogesterone acetate | Apalutamide | Darolutamide | Bicalutamide | Spironolactone | Flutamide | Danazol | Finasteride | Lupeol | ARCC-4 | 11-Ketodihydrotestosterone | Alpha-Estradiol | Ailanthone | Dutasteride | BMS-564929 | UT-34 | 3,3'-Diindolylmethane | VPC-14449 | PROTAC AR-V7 degrader-1 | AZD3514 | EPI-001 | Nilutamide | Ralaniten | Adrenocorticotropic hormone TFA | Drospirenone | Masofaniten
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Isolation and Culture of Megakaryocyte Precursors
34 + antigen and are either CD38 – or CD38 + , depending upon their maturation stage. The most primitive progenitors (BFU-MK and the mixed erythro-MK progenitors) are negative for CD38, while the others are CD38 positive ( 2 ). Other differentiation markers
the subcellular distribution of the MK2–EGFP as a direct readout of p38 activation. The MK2–EGFP translocation assay performed in 384-well glass bottom microtiter plates exhibited a robust Z-factor of 0.46 and reproducible EC50 and IC50 determinations
γ。 本信号转导涉及的信号分子 主要包括 GPCR，TGF-β，FasL，Gαo，TRADD，TRAF2，RIP，Daxx，TAO1，TAO2，TAO3，DLK，MEKK1，MEKK2，MEKK3，MEKK4，MLK2，MLK3，ASK1，TAB1，ASK2，MKK3，MKK4，MKK6，p38 MAPK，eEF2K，MNK1，MNK2，cPLA2，Tau，PRAK，MK2，MK3，MK2，HSP27，MSK1，MSK2，Pax6，p53，Stat1，Max，Myc，Elk
技术资料暂无技术资料 索取技术资料
