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Glutaminyl Cyclase Inhibitor 5
MCE 国际站：Glutaminyl Cyclase Inhibitor 5
产品活性：Glutaminyl Cyclase Inhibitor 5 (Compound 71) 是一种有效的、选择性的人谷氨酰胺酰基环化酶 (hQC) 抑制剂，IC50 为 3.2 nM。
研究领域：Neuronal Signaling
作用靶点：Amyloid-β
In Vitro: Glutaminyl Cyclase Inhibitor 5 (Compound 71) does not show significant hERG inhibition (47.6% inhibition at 10 μM).
Glutaminyl Cyclase Inhibitor 5 exhibits reasonable permeability with less than a cutoff value of 6.0 (-log Pe) and is likely to be BBB permeable.
In Vivo: Glutaminyl Cyclase Inhibitor 5 (Compound 71) (10 mM, 5 μL; ICV; once) suppresses the formation of pE-Aβ3-40 by 25% in acute Alzheimer's disease mouse model.
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文献和实验浅析染色质免疫沉淀（ChIP）技术在 DNA 与蛋白质相互作用研究中的重要性
analysis reveals genes associated with the ability of MYC to maintain tumorigenesis. PLoS Genet, 2008. 4(6): p. e1000090. [6] Guo, H., et al., Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding
Determination of NOS Activity Using Cyclic-GMP Formation
which diffuses from the originator cell to affect other “target” cells in a paracrine manner. NO effects on cells include adenine diphosphate (ADP)-ribosylation and nitrosation/nitration of proteins, and the activation of soluble guanylyl cyclase (GC-S) to form
correct reconstruction of A53T and A30P.（8）结果:DNA测序结果证明构建载体插入正确α-突触核蛋白突变体A53T与A30P基因。（9）METHODS: RKO cells were treated with selective DNA methyltransferase (DNMTs) inhibitor, 5-Aza-2′-deoxycytidine (5-Aza-CdR), for 72 h. Methylation-specific PCR (MSP), T
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