AZT triphosphate tetraammonium

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AZT triphosphate tetraammonium

CAS No. : 106060-92-8

MCE 国际站：AZT triphosphate tetraammonium

产品活性：AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium 是一种 Zidovudine (AZT) 的活性三磷酸酯代谢产物。AZT triphosphate tetraammonium 具有抗逆转录病毒的活性，并抑制 HIV 复制。AZT triphosphate tetraammonium 还可抑制 HBV 的 DNA 聚合酶。AZT triphosphate tetraammonium 可激活线粒体介导的凋亡 (apoptosis) 途径。

研究领域：Anti-infection  |  Cell Cycle/DNA Damage  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：HIV  |  DNA/RNA Synthesis  |  HBV  |  Reactive Oxygen Species  |  Apoptosis

In Vitro: AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium accumulation disrupts the mitochondrial tubular network in H9c2 cells through Treatment with 100 µM Zidovudine (AZT) for 48h. AZT triphosphate tetraammonium accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate tetraammonium causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts.

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