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Sp-cAMPS triethylamine
CAS No. : 93602-66-5
MCE 国际站：Sp-cAMPS triethylamine
产品活性：Sp-cAMPS triethylamine，一种 cAMP 类似物，是一种依赖 cAMP 的 PKA I 和 PKA II 的有效激活剂。Sp-cAMPS triethylamine 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 µM。Sp-cAMPS triethylamine 以 EC50 为 40 μM 来结合 PDE10 GAF 域。
研究领域：Stem Cell/Wnt | Metabolic Enzyme/Protease
作用靶点：PKA | Phosphodiesterase (PDE)
In Vitro: Treatment of hepatocytes with Sp-cAMPS triethylamine, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca2+ can be mimicked by Sp-cAMPS triethylamine.
In Vivo: In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) triethylamine into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals.
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