Spicamycin,87099-85-2

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Spicamycin

CAS No. : 87099-85-2

MCE 国际站：Spicamycin

产品活性：Spicamycin 是一种具有抗真菌和抗肿瘤活性的腺嘌呤核苷类抗生素。Spicamycin 也是髓系白血病细胞分化的有效诱导剂。Spicamycin 通过下调 Bcl-2 表达和调节 PML 蛋白诱导 NB4 细胞凋亡 (apoptosis)。

研究领域：Apoptosis  |  Anti-infection

作用靶点：Bcl-2 Family  |  Apoptosis  |  Fungal  |  Antibiotic

In Vitro: Spicamycin (10-160 ng/mL; 0-5 d) potently inhibits cell proliferation and viability of NB4, NKM-1, and HL-60 cells.
Spicamycin (20 ng/mL, 80 ng/mL; 48 h) induces apoptosis in NB4, HL-60 and NKM-1 cells.
Spicamycin (20 ng/mL, 40 ng/mL; 36 h) down-regulates the Bcl-2 expression in NB4 cells.
Spicamycin (2.5-640 ng/mL) shows anti-microbial activity against Saccharomyces cerevisiae ATCC 9763, Candida utilis IFO 0396, and Trichophyton mentagrophytes with MIC values of 25μg/mL, 25μg/mL, and 1.56 μg/mL, respectively。

In Vivo: Spicamycin (0.125-2 mg/kg; i.p.; once daily for 9 d) shows anti-tumor activity against P388 Mouse Leukemia model.
Spicamycin shows an LD₅₀ value of 40 mg/kg (i.p.) in mice.

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