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Please store the product under the recommended conditions in the Certificate of Analysis.
- 英文名：
SIN-1; Linsidomine
- 库存：
货期：电询
- 供应商：
MedChemExpress LLC
- CAS号：
33876-97-0
- 规格：
电询
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3-Morpholinosydnonimine
CAS No. : 33876-97-0
MCE 国际站：3-Morpholinosydnonimine
产品活性：3-Morpholinosydnonimine (SIN-1; Linsidomine) 是一种自发的 ROS/RNS 发生因子和过氧亚硝酸盐供体。3-Morpholinosydnonimine 能够抑制肥大软骨细胞活力，并诱导坏死 (necrosis)。3-Morpholinosydnonimine 诱导 p53 依赖性凋亡 (apoptosis)，诱导 p53 积聚和激活 MAPK 磷酸化。
研究领域：Apoptosis
作用靶点：MDM-2/p53
In Vitro: 3-Morpholinosydnonimine (1, 3, and 5 mM; 24 h) inhibits hypertrophic chondrocytes viability.
3-Morpholinosydnonimine (3 mM, and 5 mM; 24 h) induces necrosis death in hypertrophic chondrocytes, as well as inducing apoptosis death in both ATDC5 cells and C28/I2 cells.
3-Morpholinosydnonimine (50 μM, 200 μM, and 400 μM; 6 h) induces a rapid increase in expression of p53 and induce p53-dependent apoptosis in neuron-rich mouse telencephalic cells.
3-Morpholinosydnonimine (200 μM; 6 h) induces p53 accumulation through p21(ras) activation.
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文献和实验-free radical oxidants through use of diethylamine NONOate, 3-morpholinosydnonimine (SIN-1), and a synthetic preparation of peroxynitrite (PN). The viability of control and the treated H9c2 cells was measured based on the reduction of resazurin
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