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Telomerase-IN-5
CAS No. : 2892295-16-6
MCE 国际站：Telomerase-IN-5
产品活性：Telomerase-IN-5 是一种有效的端粒酶 (telomerase) 抑制剂。Telomerase-IN-5 具有抗增殖活性，诱导细胞凋亡 (apoptosis)。
研究领域：Apoptosis
作用靶点：Apoptosis
In Vitro: Telomerase-IN-5 (compound 9e; 0.1-100 μg/mL; 72 h) has antitumor effects against both cancer cell lines with IC50 values of 34.53 and 63.85 μg/mL for MCF-7 and A549 cells, respectively.
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文献和实验Telomerase, a ribonucleoprotein enzyme, is detected in the vast majority of cancers, including malignant gliomas, but not in most normal somatic cells. To inhibit telomerase function effectively, we have adopted the 2′,5′-oligoadenylate (2-5
Analysis of Telomerase RNA Gene Expression by In Situ Hybridization
The regulation of telomerase activity is likely to be a complex issue, involving the transcriptional activity of the telomerase RNA component gene, (hTR) and the telomerase catalytic component gene (hTRT), as well as the interaction
In Vivo Imaging of Human Cancer with Telomerase-Specific Replication-Selective Adenovirus
of telomeres, and its activity is closely correlated with human telomerase reverse transcriptase (hTERT) expression. We constructed a green fluorescent protein (GFP)-expressing attenuated adenovirus-5 vector, in which the hTERT promoter regulates viral
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