CYP1B1-IN-4,2685779-55-7

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CYP1B1-IN-4

CAS No. : 2685779-55-7

MCE 国际站：CYP1B1-IN-4

产品活性：CYP1B1-IN-4 是一种选择性 CYP1B1 抑制剂 (IC₅₀=0.2 nM)，是一种 2,4-二芳基噻唑化合物。CYP1B1-IN-4 的细胞毒性低，在人和大鼠肝微粒体中均具有稳定性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Cytochrome P450

In Vitro: CYP1B1-IN-4 (compound 15) (100 μM; 37 ℃; 0-60 min) has in vitro stability in both human and rat liver microsomes, while it has low stability in mouse liver microsomes.
CYP1B1-IN-4 (1 nM-10 μM) also inhibits CYP1A1 with an IC₅₀ value of 3.82 μM.
CYP1B1-IN-4 (200 μM; 72 h) parental HEK T-REx cell line , and (100 μ M; 72 h) has little cytotoxicity in HEK293 cells.

Stability Parameters in Human, Rat, or Mouse Liver Microsomes

Parameters	T1/2 (min)	CLint(mic) (μL/min/mg)	CLint(liver) (mL/min/kg)	% remainingT=60 min
Human	28.3	49.0	44.1	19.0
Rat	36.6	37.9	68.2	27.1
Mouse	2.5	545.9	2161.9	0.2

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