Anti-TNIP1 Polyclonal Antibody

Anti-TNIP1 Polyclonal Antibody



产品简介

英文名称	Anti-TNIP1 Polyclonal Antibody
靶标	TNIP1
别名	ABIN-1;Naf1;Nip40-1;VAN;hVAN;KIAA0113;NAF1;
宿主	Rabbit
稀释比例	WB 1:1000-3000. IHC 1:100-300.
Gene ID	10318
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q15025
蛋白分子量	62/63/64/65/66/72kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Nucleus
免疫原	Recombinant protein of human TNIP1
亚型	IgG
纯化方法	Octanoic acid-ammonium sulfate precipitation
背景资料	Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. In case of infection, promotes association of IKBKG with Shigella flexneri E3 ubiquitin-protein ligase ipah9.8 p which in turn promotes polyubiquitination of IKBKG leading to its proteasome-dependent degradation and thus is perturbing NF-kappa-B activation during bacterial infection.
Public Immunogen Range	1-350aa
克隆类型	Polyclonal Antibody
交叉反应	Human Mouse
应用	WB IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Western blot analysis with TNIP1 antibody diluted at 1:2000;Lane:A-431,U251

Immunohistochemistry of paraffin-embedded Human breast cancer with TNIP1 antibody diluted at 1:200

Immunohistochemistry of paraffin-embedded Human colorectal cancer with TNIP1 antibody diluted at 1:200