Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚型:
IgG
免疫原:
Recombinant protein of human VWA5A
产品简介
单位
支
英文名称
Anti-VWA5A Polyclonal Antibody
别名
BCSC1;BCSC-1;LOH11CR2A
宿主
Rabbit
稀释比例
WB 1:500-2000. IHC 1:50-150.
Gene ID
4013
保存
Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot
O00534
蛋白分子量
86 kDa
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位
Cytoplasm
免疫原
Recombinant protein of human VWA5A
亚型
IgG
纯化方法
Affinity purification
背景资料
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.
克隆类型
Polyclonal Antibody
交叉反应
Human
应用
WB IHC
规格
50ul 100ul
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示:
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Western blot analysis with VWA5A antibody diluted at 1:1000;Lane: Jurkat,A549,293T,HepG2,HMC-1,Hela
Immunohistochemistry of paraffin-embedded Human liver cancer with VWA5A antibody diluted at 1:60