Anti-MAP3K5 Polyclonal Antibod

产品简介

单位	支
英文名称	Anti-MAP3K5 Polyclonal Antibody
别名	ASK1;MAPKKK5;MEKK5
宿主	Rabbit
稀释比例	IHC 1:10-100.
Gene ID	4217
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q99683
蛋白分子量	70/154kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Endoplasmic reticulum
免疫原	A synthetic peptide of human MAP3K5
亚型	IgG
纯化方法	Affinity purification
背景资料	Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
克隆类型	Polyclonal Antibody
交叉反应	Human Mouse
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Immunohistochemistry of paraffin-embedded Human colorectal cancer with MAP3K5 antibody diluted at 1:20