DX254E;DXS254E;G6PD;GDX;OTTHUMP00000061462;Ubiquitin like 4;Ubiquitin like 4A;Ubiquitin like protein 4A;Ubiquitin like protein GDX;Ubiquitin-like protein 4A;Ubiquitin-like protein GDX;UBL 4;UBL 4A;UBL4;Ubl4a;UBL4A_HUMAN;
背景资料
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD, a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
Swiss Prot
P11441
Gene ID
8266
亚细胞定位
Cytoplasm Nucleus
宿主
Rabbit
克隆类型
Polyclonal Antibody
亚型
IgG
预测交叉反应
Zebrafish;Sablefish;Rabbit;Horse;Monkey;Gorilla
蛋白分子量
18kDa
稀释比例
IHC 1:25-100.
免疫原
Recombinant protein of human UBL4A
Public Immunogen Range
1-158aa
纯化方法
Affinity purification
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
保存
Store at -20℃. Avoid freeze / thaw cycles.
交叉反应
Human Mouse Rat
应用
IHC
规格
50ul 100ul
单位
支
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示:
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Immunohistochemistry of paraffin-embedded human testis cancer with UBL4A antibody diluted at 1:50.