Anti-LATS1/LATS2 Polyclonal An

产品简介

靶标	LATS1/LATS2
别名	h-warts; Large tumor suppressor homolog 1; LATS large tumor suppressor homolog 1; LATS1; LATS1_HUMAN; Serine threonine protein kinase LATS1; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts;
背景资料	The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Swiss Prot	O95835/Q9NRM7
亚细胞定位	Cytoplasm
宿主	Rabbit
克隆类型	Polyclonal Antibody
亚型	IgG
蛋白分子量	76/127KDa
稀释比例	IHC 1:50-200.
免疫原	A synthetic peptide of human LATS1/LATS2
Public Immunogen Range	800-850/1130aa
纯化方法	Octanoic acid-ammonium sulfate precipitation
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
保存	Store at -20℃. Avoid freeze / thaw cycles.
交叉反应	Human;Mouse
应用	IHC
规格	50ul 100ul
单位	支

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Immunohistochemistry of paraffin-embedded human colorectal cancer with LATS1/LATS2 antibody diluted at 1:100.

Immunohistochemistry of paraffin-embedded human renal cancer with LATS1/LATS2 antibody diluted at 1:100.