Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
Swiss Prot
Q8WYR1
亚细胞定位
Cytoplasm Nucleus
宿主
Rabbit
克隆类型
Polyclonal Antibody
亚型
IgG
预测交叉反应
Chicken;Pig
蛋白分子量
55/97kDa
实际分子量
55kDa
稀释比例
WB 1:2000-5000. IHC 1:25-100.
免疫原
Recombinant protein of human PIK3R5
Public Immunogen Range
1-495aa
纯化方法
Affinity purification
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
保存
Store at -20℃. Avoid freeze / thaw cycles.
交叉反应
Human;Mouse
应用
WB;IHC
规格
50ul 100ul
单位
支
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示:
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Western blot analysis with PIK3R5 antibody diluted at 1:3000;Lane: U251.
Immunohistochemistry of paraffin-embedded human colorectal cancer with PIK3R5 antibody diluted at 1:50.
Immunohistochemistry of paraffin-embedded human pancreatic cancer with PIK3R5 antibody diluted at 1:50.