Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法
Affinity purification
亚型
IgG
免疫原
A synthetic peptide of human SH2D1B
亚细胞定位
Cytoplasm
Swiss Prot
O14796
背景资料
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation . Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling . In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse . Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation.
Public Immunogen Range
45-95/132aa
克隆类型
Polyclonal Antibody
交叉反应
Human
应用
WB
规格
50ul 100ul
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图
Western blot analysis with SH2D1B antibody diluted at 1:2000;Lane: Jurkat,PC-3,K-562