Anti-TNFSF11 Polyclonal Antibo

产品简介

单位	支
英文名称	Anti-TNFSF11 Polyclonal Antibody
别名	CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoprotegerin ligand, RANKL, sOdf, TNFSF11, TRANCE
中文名称	肿瘤坏死因子-α(配体)超家族成员11抗体
宿主	Rabbit
稀释比例	WB 1:500-2000.IF 1:50-200
Gene ID	8600
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	O14788
蛋白分子量	27/30/35kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cell membrane Cytoplasm Secreted Single-pass type II membrane protein Single-pass type II membrane protein
免疫原	Recombinant protein of human TNFSF11
亚型	IgG
纯化方法	Affinity purification
背景资料	This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IF
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Western blot analysis with Anti-TNFSF11 Rabbit Polyclonal Antibody diluted at 1:1,000