CPE binding protein 4; CPE-binding protein 4; CPE-BP4; cpeb4; CPEB4_HUMAN; Cytoplasmic polyadenylation element binding protein 4; Cytoplasmic polyadenylation element-binding protein 4; hCPEB-4; KIAA1673;
背景资料
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (By similarity). Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation. Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT. Stimulates proliferation of melanocytes. In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory (By similarity).
Swiss Prot
Q17RY0
Gene ID
80315
亚细胞定位
Cytoplasm
宿主
Rabbit
克隆类型
Polyclonal Antibody
亚型
IgG
预测交叉反应
Zebrafish
蛋白分子量
36/78/80kDa
稀释比例
WB 1:1000-3000.; IHC 1:100-300.
免疫原
Recombinant protein of human CPEB4
Public Immunogen Range
1-323aa
纯化方法
Affinity purification
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4.
保存
Store at -20°C. Avoid freeze / thaw cycles.
交叉反应
Human Mouse
应用
WB IHC
规格
50ul 100ul
单位
支
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示:
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Western blot analysis with CPEB4 antibody diluted at 1:2000;Lane: 293T,T47d.
Immunohistochemistry of paraffin-embedded Human Liver cancer with CPEB4 antibody diluted at 1:200.