ANKRD4, Ankyrin repeat domain containing protein 4, ankyrin repeat domain protein 4, Ankyrin repeat domain-containing protein 4, CAAX box protein TIMAP, hTIMAP, KIAA0823, PP16B_HUMAN, PPP1R16B, Protein phosphatase 1 regulatory inhibitor subunit 16B, protein phosphatase 1, regulatory (inhibitor) subunit 16B, TGF beta inhibited membrane associated protein, TGF-beta-inhibited membrane-associated protein, TIMAP
背景资料
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934).
Swiss Prot
Q96T49
Gene ID
26051
亚细胞定位
Cytoplasm Nucleus
宿主
Rabbit
克隆类型
Polyclonal Antibody
亚型
IgG
预测交叉反应
Cow;Xenopus tropicalis
蛋白分子量
59/64kDa
稀释比例
WB 1:1000-3000.
免疫原
A synthetic peptide of human PPP1R16B
Public Immunogen Range
15-65/567aa
纯化方法
Affinity purification
储存液
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4.
保存
Store at -20°C. Avoid freeze / thaw cycles.
交叉反应
Human;Mouse
应用
WB
规格
50ul 100ul
单位
支
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示:
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Western blot analysis with PPP1R16B antibody diluted at 1:2000;Lane: SH-SY5Y,Jurkat.