Anti-GDF1 Polyclonal Antibody

Anti-GDF1 Polyclonal Antibody

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  • ¥960 - 1600
  • Solarbio已认证
  • 北京
  • 2025年07月14日
  • IHC
  • Rabbit
  • Human
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    • 详细信息
    • 技术资料
    • 免疫原

      A synthetic peptide of human GDF1

    • 亚型

      IgG

    • 形态

      冻干粉

    • 保存条件

      Store at -20°C. Avoid freeze / thaw cycles.

    • 克隆性

      单克隆

    • 标记物

      Secreted

    • 适应物种

      Human

    • 保质期

      现询客服

    • 抗原来源

      A synthetic peptide of human GDF1

    • 库存

      999

    • 宿主

      Rabbit

    • 应用范围

      IHC

    • 浓度

      IHC 1:50-200.

    • 靶点

      GDF1

    • 抗体英文名

      Anti-GDF1 Polyclonal Antibody

    • 抗体名

      DORV;DTGA3;Embryonic growth/differentiation factor 1;GDF 1;GDF-1;GDF1;GDF1_HUMAN;Growth differentiation factor 1;

    • 规格

      50ul/100ul

    规格:50ul产品价格:¥960.0
    规格:100ul产品价格:¥1600.0
    产品简介
    英文名称 Anti-GDF1 Polyclonal Antibody
    宿主 Rabbit
    别名 DORV;DTGA3;Embryonic growth/differentiation factor 1;GDF 1;GDF-1;GDF1;GDF1_HUMAN;Growth differentiation factor 1;
    稀释比例 IHC 1:50-200.
    蛋白分子量 39/45kDa
    Gene ID 2657
    保存 Store at -20°C. Avoid freeze / thaw cycles.
    储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
    纯化方法 Affinity purification
    亚型 IgG
    免疫原 A synthetic peptide of human GDF1
    亚细胞定位 Secreted
    Swiss Prot P27539
    背景资料 Growth and Differentiation Factor 1 (GDF?1) is a secreted protein in the TGF? beta superfamily (1). It is the functional equivalent of frog, zebrafish, and chick Vg1 (2, 3). Human GDF?1 is synthesized as a preproprotein that produces an approximately 44 kDa proprotein after cleavage of a 29 amino acid (aa) signal peptide. Further proteolysis at a dibasic cleavage site produces a 224 aa propeptide and a secreted 119 aa, 12?15 kDa mature peptide (4). Mature human GDF?1 shares 81% aa sequence identity with mouse and rat GDF?1. GDF?1 is expressed in the developing and adult nervous system, particularly in neurons of the cerebral cortex and hippocampus (4, 5). It is required during embryogenesis for development of left/right axis asymmetry, anterior/posterior axis asymmetry, and the notochord (2, 3, 6, 7). It cooperates with Nodal and GDF?3 in these activities and potentiates Nodal bioactivity through formation of a 27 kDa noncovalent GDF?1?Nodal heterodimer (3, 7, 8). The presence of Nodal is required for GDF?1 induced effects (8). GDF?1 signals through heteromeric receptor complexes containing Activin RIIA or Activin RIIB, ALK4 or ALK7, and an EGF?CFC protein such as Cryptic or Cripto (7?9). Loss of function mutations in GDF?1 are associated with a variety of human cardiac development defects (10).
    Public Immunogen Range 90-140/372aa
    克隆类型 Polyclonal Antibody
    交叉反应 Human
    应用 IHC
    规格 50ul 100ul

    备注:
    以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
    These protocols are for reference only. Solarbio does not independently validate these methods.
    实验图
    Anti-GDF1 Polyclonal Antibody
    Immunohistochemistry of paraffin-embedded Human colorectal cancer with GDF1 antibody diluted at 1:100

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