Anti-HSP90B1 Polyclonal Antibo

产品简介

单位	支
英文名称	Anti-CALR Polyclonal Antibody
别名	CRT;HEL-S-99n;RO;SSA;cC1qR
宿主	Rabbit
稀释比例	WB 1:1000-5000. IHC 1:50-200.
Gene ID	811
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P27797
蛋白分子量	48kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cell surface Cytoplasm Endoplasmic reticulum lumen Sarcoplasmic reticulum lumen Secreted cytosol extracellular matrix extracellular space
免疫原	Recombinant protein of human CALR
亚型	IgG
性状	液体
纯化方法	Affinity purification
背景资料	Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.
Public Immunogen Range	Recombinant protein of human CALR
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Western blot analysis with CALR antibody diluted at 1:2500; Lane:HepG2,HL-60

Immunohistochemistry of paraffin-embedded Human ovarian cancer with CALR antibody diluted at 1:50