Anti-FEN1 Polyclonal Antibody

产品简介

英文名称	Anti-FEN1 Polyclonal Antibody
宿主	Rabbit
别名	FEN-1;MF1;RAD2;DNase IV;Flap endonuclease 1;flap structure endonuclease 1;hFEN 1;Maturation factor 1
稀释比例	IHC 1:50-200.
蛋白分子量	36/43kDa
Gene ID	2237
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Octanoic acid-ammonium sulfate precipitation
亚型	IgG
免疫原	Recombinant protein of human FEN1
性状	液体
亚细胞定位	Mitochondrion Nucleus nucleolus nucleoplasm
Swiss Prot	P39748
背景资料	The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
Public Immunogen Range	1-380aa
克隆类型	Polyclonal Antibody
交叉反应	Human
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry?of?paraffin-embedded?Human breast cancer?with?FEN1 antibody diluted at 1:50