- ￥960 - 1600
- Solarbio
- 北京
- K003227P
- 2025年07月15日
- Rabbit
- Human Mouse Rat
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- 详细信息
- 技术资料
- 免疫原：
Recombinant protein of human PTEN
- 亚型：
IgG
- 形态：
液体
- 保存条件：
Store at -20°C. Avoid freeze / thaw cycles.
- 克隆性：
单克隆
- 适应物种：
Human Mouse Rat
- 目录编号：
K003227P
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 靶点：
PTEN
- 抗体英文名：
Anti-PTEN Polyclonal Antibody
- 抗体名：
10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥960.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 英文名称 | Anti-PTEN Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | 10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1 |
| 稀释比例 | WB 1:500-2000. IHC 1:50-200. |
| 蛋白分子量 | 47kDa |
| Gene ID | 5728 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human PTEN |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human PTEN |
| 亚细胞定位 | Cytoplasm Nucleus PML body Secreted |
| Swiss Prot | P60484 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. |
| 应用 | WB IHC |
| 交叉反应 | Human Mouse Rat |
| 规格 | 50ul 100ul |
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Anti-PTEN Polyclonal Antibody
￥960 - 1600
