Store the anti-MUC1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
亚型:
Mouse IgG1, kappa
免疫原:
Breast cancer cell line ZR75-1 was used as the immunogen for the anti-MUC1 antibody.
规格:
20 ug
This mAb reacts with MUC1/Mucin-1/Epithelial Marker Antigen/EMA. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in > 90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
产品名:MUC1 antibody / Mucin-1
货号:orb749684
产品中文名:MUC1 抗体 / Mucin-1
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