Store the Superoxide Dismutase 1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
亚型:
Mouse IgG1, kappa
免疫原:
A portion of amino acids 14-148 from the human protein was used as the immunogen for the Superoxide Dismutase 1 antibody.
规格:
20 ug
Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.
产品名:SOD1 antibody / Superoxide Dismutase 1
货号:orb699686
产品中文名:SOD1 抗体 / Superoxide Dismutase 1
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