关键词:AF/LE Purified Anti-Mouse CD45R/B220 Monoclonal Antibody,AF/LE Purified 抗小鼠 CD45R/B220单克隆抗体,AF/LE Purified 抗小鼠 CD45R/B220单克隆抗体,AF/LE Purified Anti-Mouse CD45R/B220 Monoclonal Antibody
产品名称:AF/LE Purified 抗小鼠 CD45R/B220单克隆抗体-AF/LE Purified Anti-Mouse CD45R/B220 Monoclonal Antibody
产品货号:RD21360F
产品规格:50ug#500ug#1mg
应用类型:Cell Sep-Neg, Depletion, FCM, IHC, IP
保存建议:AF/LE Purified 抗小鼠 CD45R/B220单克隆抗体-AF/LE Purified Anti-Mouse CD45R/B220 Monoclonal Antibody2~8 ℃保存。 请勿冷冻。
背景资料:该AF/LE Purified Anti-Mouse CD45R/B220 Monoclonal Antibody. CD45, also known as leukocyte common antigen (LCA), B220, and T200, is a 180-2CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.40 kD single chain type I membrane glycoprotein. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 is one of the best negative selection markers for characterizing and/or isolating human mesenchymal stem cells from bone marrow and other sources.
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