产品名称:LRP2BP抗体 产品分类 抗体 / 一抗 英文名称 LRP2BP 中文名称 低密度脂蛋白相关蛋白2结合蛋白抗体 英文别名 DKFZp761O0113; FLJ44965; KIAA1325; LR2BP_HUMAN; LRP2 binding protein; LRP2-binding protein; Lrp2bp; Megalin binding protein; Megalin-binding protein; MegBP. 英文别名 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep 标记 Unconjugated 抗体来源 Rabbit 抗体类型 Polyclonal 免疫原 KLH conjugated synthetic peptide derived from human LRP2BP 蛋白细胞定位 细胞浆 纯化方法 affinity purified by Protein A 亚型 IgG 性状 Liquid 浓度 1mg/ml 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料 LRP2BP is a 347 amino acid protein that contains one TPR repeat and six Sel1-like repeats. Localized to the plasma membrane and throughout the cytoplasm, LRP2BP interacts with megalin (also known as LRP2) and, via this interaction, is thought to regulate megalin function. Specifically, LRP2BP acts as a scaffold protein that, through its TPR motifs, assists in the sequestration and/or the release of transcription factors that influence megalin’s affects on endocytosis and hormone release. LRP2BP is expressed in colon, testis, small intestine and blood leukocytes, as well as in pancreatic adenocarcinoma cells, suggesting a possible role for LRP2BP in carcinogenesis. Two isoforms of LRP2BP exist due to alternative splicing events.