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说明书
说明书
说明书
单克隆
Rabbit
说明书
MRM1
MRM1抗体
Unconjugated
说明书
说明书
说明书
IgG
液体
仅供科研实验
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed
1mg/ml
100ul
产品名称 | 英文名称 | 型号 |
MRM1抗体 | MRM1 | GOY-01K5406 |
产品名称:MRM1抗体 产品分类 抗体 / 一抗 英文名称 MRM1 中文名称 线粒体rRNA甲基转移酶1抗体 英文别名 A530065E19Rik; ENSMUSG00000054212; FLJ22578; Mitochondrial large ribosomal RNA ribose methylase; Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae); MRM1; MRM1_HUMAN; OTTMUSP00000008034; RGD1566232; RP23-293L24.6; rRNA methyltransferase 1, mitochondrial. 交叉反应 Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep 标记 Unconjugated 抗体来源 Rabbit 抗体类型 Polyclonal 免疫原 KLH conjugated synthetic peptide derived from human MRM1 蛋白细胞定位 细胞浆 纯化方法 affinity purified by Protein A 亚型 IgG 性状 Liquid 浓度 1mg/ml 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料 MRM1 is a 353 amino acid protein that localizes to the mitochondrion and belongs to the RNA methyltransferase trmH family. Expressed as two alternatively spliced isoforms, MRM1 specifically methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S). The gene encoding MRM1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. |
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