产品名称:RNF207抗体 产品分类 抗体 / 一抗 英文名称 RNF207 中文名称 环指蛋白207抗体 英文别名 FLJ46380; C1orf188; D330010C22Rik; FLJ32096; FLJ46380; FLJ46593; Gm143; Ring finger protein 207; RN207_HUMAN; RNF 207; RNF207; RP23-421E12.8. 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep 标记 Unconjugated 抗体来源 Rabbit 抗体类型 Polyclonal 免疫原 KLH conjugated synthetic peptide derived from human RNF207 蛋白细胞定位 细胞核,细胞浆 纯化方法 affinity purified by Protein A 亚型 IgG 性状 Liquid 浓度 1mg/ml 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料 Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.