Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed
浓度:
1mg/ml
规格:
100ul
产品属性:
产品名称
英文名称
型号
CENTD1抗体
CENTD1
GOY-01K4665
产品名称:CENTD1抗体 产品分类 抗体 / 一抗 英文名称 :CENTD1 中文名称:CENTD1蛋白抗体 英文别名 :ARAP2; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 2; Centaurin delta 1; Cnt d1; FLJ13675; KIAA0580; PARX protein. 交叉反应 :Human, Mouse, Rat, Pig, Cow, Horse, Sheep 标记 :Unconjugated 抗体来源:Rabbit 抗体类型:Polyclonal 免疫原:KLH conjugated synthetic peptide derived from human CENTD1 蛋白细胞定位:细胞浆 纯化方法:affinity purified by Protein A 亚型:IgG 性状:Liquid 浓度:1mg/ml 储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料 The protein encoded by this e contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics.The ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organ-ization and cell adhesion. These proteins are best characterized as regulators of membrane traffic. The Centaurin GTPase-activating protein family comprise a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of ARF-dependent pathways. This family includes ARAP2, a GTPase-activating protein that controls Actin cytoskeleton remodeling by regulating Rho ARF family members. The ARAP2 protein localizes to the cytoplasm and is expressed in various tissues including brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. It contains one ARF-GAP domain, five PH domains, one Ras-associating domain, one Rho-GAP domain and one SAM (sterile a motif) domain.