产品名称:C1orf83抗体 产品分类 抗体 / 一抗 英文名称 :C1orf83 中文名称:1号染色体开放阅读框83抗体 英文别名 :chromosome 1 open reading frame 83; FLJ32112; FLJ39169; hypothetical protein LOC127428; Uncharacterized protein C1orf83; TEAN2_HUMAN. 交叉反应 :Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep 标记 :Unconjugated 抗体来源:Rabbit 抗体类型:Polyclonal 免疫原:KLH conjugated synthetic peptide derived from human C1orf83 蛋白细胞定位:细胞核 纯化方法:affinity purified by Protein A 亚型:IgG 性状:Liquid 浓度:1mg/ml 储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件:Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料 Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human ome. There are about 3,000 es on chromosome 1, and considering the great number of es there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA e which encodes lamin A. When defective, the LMNA e product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH e is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 e and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf83 e product has been provisionally designated C1orf83 pending further characterization. There are two isoforms of C1orf83 that are produced as a result of alternative splicing events.