KLH conjugated synthetic peptide derived from human Hepatitis C Virus E2
亚型:
LgG
形态:
液体
应用范围:
说明书
保存条件:
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
浓度:
1mg/ml
规格:
100ul
产品属性:
产品名称
丙型肝炎病毒E2抗体
浓度
1mg/ml
型号
EY-01K4726
产品名称:丙型肝炎病毒E2抗体 英文名称:Hepatitis C Virus E2 英文别名:Core protein; Hepatitis C virus subtype 1b; E1 protein; E2 protein; Envelope glycoprotein E2; gp68; gp70; HCV E2; NS1; NS2 protein; NS3 protease/helicase; NS4A protein; NS4B protein; NS5A protein; NS5B RNA dependent RNA polymerase; P7 protein. 标记: Unconjugated 抗体来源: Rabbit 抗体类型: Polyclonal 免疫原: KLH conjugated synthetic peptide derived from human Hepatitis C Virus E2 纯化方法: Affinity purified by Protein A 亚型: IgG 性状: Liquid 浓度: 1mg/ml 储存液: Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 保存条件: Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料: Hepatitis C E2 is a virus envelope glycoprotein which forms a heterodimer with the E1 protein. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.