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说明书
说明书
说明书
单克隆
Rabbit
说明书
Smad3
细胞信号转导分子SMAD3重组兔单克隆抗体
Unconjugated
说明书
说明书
Recombinant human Smad3 protein (1-200aa)
LgG
液体
说明书
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
1mg/ml
100ul
产品名称 | 浓度 | 型号 |
细胞信号转导分子SMAD3重组兔单克隆抗体 | 1mg/ml | EY-01K2011 |
产品名称:细胞信号转导分子SMAD3重组兔单克隆抗体 英文名称:Smad3 英文别名:hMAD 3; hSMAD3; HSPC193; JV15 2; JV152; MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD3; MADH 3; MADH3; Mothers against decapentaplegic homolog 3; Mothers against DPP homolog 3; SMA and MAD related protein 3; SMAD 3; SMAD; SMAD-3; SMAD3_HUMAN. 交叉反应: Human, Mouse, Rat 标记: Unconjugated 抗体来源: Rabbit 抗体类型: Monoclonal 克隆号: 3D1 免疫原: Recombinant human Smad3 protein (1-200aa) 蛋白细胞定位: 细胞核,细胞浆 纯化方法: affinity purified by Protein A 亚型: IgG 性状: Liquid 浓度: 1mg/1ml 储存液: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件: Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料: Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling. |
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