Desmethylicaritin,28610-31-3

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Desmethylicaritin

CAS No. : 28610-31-3

MCE 国际站：Desmethylicaritin

产品活性：去甲基胞菌素 (Desmethylicaritin) 是一种植物雌激素分子，对胚胎干细胞向心肌细胞定向分化有诱导作用。去甲基胞菌素也通过 Wnt/β-catenin 信号通路抑制脂肪生成。

研究领域：Stem Cell/Wnt

作用靶点：Wnt

In Vitro: Desmethylicaritin is a bioactive metabolite of Epimedium flavonoids in serum.
Desmethylicaritin (0.1, 1, and 10 μM; 48 h) suppresses the adipogenesis and inhibited clonal expansion during adipogenesis in 3T3-L1 cells in a dose-dependent manner.
Desmethylicaritin (10 μM; 48 h) does not affect CCAAT/enhancer binding protein δ and β mRNA expression, but decreases the mRNA expression of CCAAT/enhancer binding protein α, peroxisome proliferator-activated receptor γ, adipocyte lipid-binding protein and lipoprotein lipase.
Desmethylicaritin (10 μM; 2, 4, 6, and 10 d) increases the protein expression of β-catenin both in the cytoplasm and nuclei and immunofluorescence results confirmed that desmethylicaritin increased nuclear translocation of β-catenin.

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