Isochamaejasmin异狼毒素,93859-63-3

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Isochamaejasmin

CAS No. : 93859-63-3

MCE 国际站：Isochamaejasmin

产品活性：Isochamaejasmin 是一种双黄酮类化合物，具有抗癌、抗疟原虫和杀虫活性。Isochamaejasmin 显示出有效的 NF-κB (NF-κB) 激活活性。Isochamaejasmin 可通过线粒体途径引起 AW1 细胞 DNA 损伤并诱导细胞凋亡 (apoptosis)。Isochamaejasmin 还具有中等抗疟原虫活性 (对恶性疟原虫的 IC₅₀ 为 7.3 μM) 和相对较低的细胞毒性 (CC₅₀ 为 29.0 μM)。

研究领域：NF-κB  |  Cell Cycle/DNA Damage  |  Anti-infection  |  Apoptosis

作用靶点：NF-κB  |  DNA/RNA Synthesis  |  Parasite  |  Apoptosis

In Vitro: Isochamaejasmin (6.25-100 μM; 24-72 h) shows potential toxicity against AW1 cells via time- and dose-dependent manners. Isochamaejasmin (1000 mg/L, 500 mg/L, 250 mg/L, 125 mg/L, 62.5 mg/L; 24 h, 48 h, 72 h, and 96 h) has potential toxicity against H. zea larvae via time- and dose-dependent manners.
Isochamaejasmin (40-80 μM; 24 h) causes DNA damage and increases the levels of γH2AX and OGG1 in AW1 cells. The cell cycle is arrested at the G2/M phase.
Isochamaejasmin (20-80 μM; 24 h) induces apoptosis of AW1 cells in a dose-dependent manner.
Isochamaejasmin (20-80 μM; 24 h) shows decline in the MMP, upregulation of Bax/Bcl-2 expression resulting in the release of cytochrome c into the cytosol, activation of caspase-3/9, and cleavage of PARP.
Isochamaejasmin shows a dose-dependent rise in the reactive oxygen species (ROS) levels, accumulation of a lipid peroxidation product, and inactivation of antioxidant enzymes in AW1 cells.
Isochamaejasmin induces the expression of a NF-κB-directed reporter gene in transfected HeLa cells with an EC₅₀ of 3.23 μM. The Isochamaejasmin-stimulated NF-κB reporter activity is accompanied by nuclear translocation of NF-κB proteins and is blocked by a dominant-negative construct of IκBα. Isochamaejasmin also induces time-dependent phosphorylation of the mitogen-activated protein kinases ERK1/2 and p38, and PKCδ.

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