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Antidepressant agent 4
MCE 国际站：Antidepressant agent 4
产品活性：Antidepressant agent 4 是一种具有口服活性的抗抑郁剂。Antidepressant agent 4 具有抗抑郁，抗焦虑，性能增强和促智活性。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | GPCR/G Protein
作用靶点：GABA Receptor | Melatonin Receptor | Sigma Receptor
In Vitro: Antidepressant agent 3 (compound 5f) seems to bind GABA-A, melatonin, and sigma-1 receptors in molecular modelling studies.
In Vivo: Antidepressant agent 4 (compound 5f) (10 mmol/kg; i.g.) increases motor and tentative search activity, along with higher interaction frequency and better results in a sucrose preference test of mice affected by social depression.
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文献和实验Characterization of 5‐HT1A,B and 5‐HT2A,C Serotonin Receptor Binding
Hemo‐De tissue clearing agent (Fisher) Thionin stain (see recipe ) Permount (Fisher
Overview of Experimental Models of the Blood‐Brain Barrier in CNS Drug Discovery
for human P‐gp) are cultured on a semipermeable membrane to form tight cell‐cell junctions. The inner well containing the cells is called the apical (A) compartment while the outer well is called the basolateral (B) compartment. A CNS‐active agent is added
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