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- 2025年12月05日
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4°C, sealed storage, away from moisture and light
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货期：1-2天
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MedChemExpress LLC
- CAS号：
2636839-90-0
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1 mg
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p53 Activator 3
CAS No. : 2636839-90-0
MCE 国际站：p53 Activator 3
产品活性：p53 Activator 3 (compound 87A) 是一种有效的 p53 激活剂，SC150 值 <0.05 mM。p53 Activator 3 可以结合突变体 p53 并恢复 p53 突变体结合 DNA 的能力。p53 Activator 3 具有抗肿瘤活性。
研究领域：Apoptosis
作用靶点：MDM-2/p53
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文献和实验in nude mice by 90% at a dose of 200 mg/kg。 NSC-207895 (XI-006) NSC-207895 (XI-006), also called a small-molecule p53 activator, gives rise to MCF-7 cells to experience apoptosis and decrease the viability of cancer cells
Methods to Study p53-Repressed Promoters
There is substantial evidence in the literature that, in addition to functioning as an activator of transcription, the p53 tumor suppressor protein can also function as a sequence-specific transcriptional repressor of a separate set of genes
SSCP and Sequence Analysis of p53 Mutations in Ovarian Tumors
mutations (3 ). We routinely perform a complete evaluation of the p 53 open reading frame (exons 2-11) using SSCP analysis with an estimated sensitivity of over 90% (3 ). This approach significantly enhances the detection of null mutations, especially
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