INY-03-041 trihydrochloride

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INY-03-041 trihydrochloride

CAS No. :

MCE 国际站：INY-03-041 trihydrochloride

产品活性：INY-03-041 trihydrochloride 是一种有效的、高选择性的、基于 PROTAC 的泛-AKT 降解剂，由ATP 竞争性 AKT 抑制剂Ipatasertib (HY-15186) 结合 Lenalidomide (HY-A0003，Cereblon 配体)组成。INY-03-041 trihydrochloride 可抑制 AKT1，AKT2 和 AKT3，IC₅₀ 分别为 2.0 nM，6.8 nM 和 3.5 nM。

研究领域：PROTAC  |  PI3K/Akt/mTOR

作用靶点：PROTACs  |  Akt

In Vitro: INY-03-041 (10-1000 nM; 0-24 hours) induces potent degradation of all three AKT isoforms in MDA-MB-468 cells.
INY-03-041 exhibits potent in vitro inhibition of S6K1 (IC₅₀ =37.3 nM) and PKG1 (IC₅₀ = 33.2 nM).
INY-03-041 displays enhanced anti-proliferative effects compared with Ipatasertib (HY-15186) in MDA-MB-468 and HCC1937 cells.
INY-03-041 (250 nM, 12 h) promotes sustained AKT degradation and inhibition of downstream signaling effects for up to 96 h, even after compound washout.

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