RSH-7,2764609-97-2

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RSH-7

CAS No. : 2764609-97-2

MCE 国际站：RSH-7

产品活性：RSH-7 是一种有效的 BTK 和 FLT3 抑制剂，IC₅₀ 分别为 47、12 nM。RSH-7 诱导细胞凋亡 (apoptosis) 并显示抗增殖活性。RSH-7 抑制 BTK 和 FLT3 信号转导并显示出抗肿瘤活性。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：Btk  |  FLT3

In Vitro: RSH-7 (1-1000 nM; 72 h) shows antiproliferative activities with IC₅₀s of 17, 3, 11, 930 nM for Jeko-1, MV-4-11, Molt4, K562 cells, respectively.
RSH-7 (30, 150, 750 nM; 72 h) decreases the expression of p-BTK (TYR223), p-PLCγ(Tyr1217), p-FLT3 (Tyr589), p-STAT5 (TYR694) in a dose-dependent manner.
RSH-7 (30, 150, 750 nM; 72 h) induces apoptosis and increases the expression of BAX, p53, cleaved caspase 3 in a dose dependen manner in jeko-1 cells.

In Vivo: RSH-7 (25, 50 mg/kg; i.p.; daily for 16 days) shows anti-tumor activity with significantly and dose-dependently suppresses the tumor growth in mouse.

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