Anti-inflammatory agent 33,281

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Anti-inflammatory agent 33

CAS No. : 2816993-09-4

MCE 国际站：Anti-inflammatory agent 33

产品活性：Anti-inflammatory agent 33 是一种有效的 p38α 抑制剂。Anti-inflammatory agent 33 抑制 NO 的产生。Anti-inflammatory agent 33 抑制 LPS 诱导的 iNOS、COX-2、p-p38α、p-MK2 蛋白表达。Anti-inflammatory agent 33 具有抗炎活性。

研究领域：MAPK/ERK Pathway

作用靶点：p38 MAPK

In Vitro: Anti-inflammatory agent 33 (compound 8j) (10, 5, 2.5, 1.25, 0.675 μM; 1+24 h) significantly inhibits NO production with the inhibition rate of 93.97% and the IC₅₀ value of 1.25 µM in LPS-induced RAW264.7 cells.
Anti-inflammatory agent 33 (1.25, 2.5, 5, 10, 20 µM; 1+24 h) inhibits the production of TNF-α and IL-1β with IC₅₀ values of 11.5, 8.48 μM, respectively.
Anti-inflammatory agent 33 (1, 3, 5 µM; 1+24 h) inhibits LPS-induced iNOS, COX-2, p-p38α; p-MK2 protein expression in a dose-dependent manner in RAW264.7 cells.

In Vivo: Anti-inflammatory agent 33 (10, 30 mg/kg; once a day for 14 days) shows anti-inflammatory activity in a dose-dependent manner in rats.

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